PRP (platelet-rich plasma) is made from your own blood, spun to concentrate platelets and growth factors, then injected into the knee. Several trials and reviews found PRP eased knee arthritis pain more than hyaluronic acid at 6 to 12 months. Other trials, including a 2021 trial in JAMA, found no clear benefit over a placebo injection. Evidence is still being debated.
Who it may suit
- Early to moderate knee arthritis
- People who want to delay surgery
- Some tendon problems around the knee
What to expect
- Blood drawn, processed and injected in one visit
- Often 1 to 3 sessions
- Mild soreness for a few days
- Effects build over weeks
PRP preparation differs between clinics, which partly explains mixed results. Some regenerative clinics combine PRP with stem cell injections.